A plain language summary of the impact of vaccines against flu and chickenpox in people with multiple sclerosis treated with cladribine tablets

This video is based on a plain language summary of publication published in Neurodegenerative Disease Management. The publication looks into the effect of cladribine on vaccines in people with multiple sclerosis.

Cladribine tablets work by temporarily reducing the number of lymphocytes, which are immune cells that help to fight off infections. Because of this, people with multiple sclerosis (also called PwMS) may have concerns about the effect of cladribine tablets on vaccines, as these work via immune cells to build protection against infection.

The original study was called MAGNIFY-MS, and investigated how long it takes for cladribine tablets to begin to work in people with a type of MS called highly active relapsing MS.

The MAGNIFY-MS study gave the researchers an opportunity to look at how cladribine tablets affect the way the flu and chickenpox virus vaccines work in the body.

Original publications:
A plain language summary of the impact of vaccines against flu and chickenpox in people with multiple sclerosis treated with cladribine tablets.
Klaus Schmierer, Heinz Wiendl, Celia Oreja-Guevara et al.
Neurodegenerative Disease Management (2022). https://www.futuremedicine.com/doi/10.2217/nmt-2022-0026

Varicella zoster virus and influenza vaccine antibody titres in patients from MAGNIFY-MS who were treated with cladribine tablets for highly active relapsing multiple sclerosis.
Klaus Schmierer, Heinz Wiendl, Celia Oreja-Guevara et al.
Multiple Sclerosis Journal (2022). https://journals.sagepub.com/doi/10.1177/13524585221099413